Bactrim DS contains sulfamethoxazole and trimethoprim. It is in no way related to penicillin. It is safe to take if you are allergic to penicillin. Bactrim DS is an antibiotic and belongs to a drug class called sulfonamides. Bactrim has an average rating of 4.6 out of 10 from a total of 18 ratings for the treatment of sinusitis. 33% of those users who… Continue reading Bactrim DS Oral is a strong antibiotic